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A reduction in HIF-1 activity and the expression of stemness-associated transcription factors were also detected

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Moreover, inflammatory factors activate signaling pathways within endothelial cells, such as the nuclear factor-B (NF-B) pathway, further upregulating the expression of adhesion molecules (such as ICAM-1 and VCAM-1), which facilitates leukocyte adhesion and transmigration across the endothelium, thereby exacerbating BSCB damage

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